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The Cepeda Framework: A Modular, Safety-First Preclinical Architecture for Testing Coordinated Multi-Hallmark Rejuvenation Hypotheses in Biological Aging

2026-03-17

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<h4>ABSTRACT</h4> <h4>Background</h4> The twelve hallmarks of aging as defined by López-Otín et al. ( Cell , 2023) represent the primary, antagonistic, and integrative mechanisms driving biological aging. To our knowledge, no open-source preclinical framework has yet attempted to coordinate all 12 official hallmarks in a single modular, non-integrating, safety-gated design validated across tens of thousands of...

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Literature Corpus work
9eac2b23-9630-52f7-ab7d-2481bbd515da
DOI
10.64898/2026.03.15.711859
Open publication

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The Cepeda Framework: A Modular, Safety-First Preclinical Architecture for Testing Coordinated Multi-Hallmark Rejuvenation Hypotheses in Biological AgingDOI 10.64898/2026.03.15.711859
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