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Unveiling the Biochemical Mechanisms of Aging and the Implications of Oxidative Stress on Cellular Senescence through Multi-Omics Analysis of Fibroblasts

2025-05-23

Abstract excerpt

This research investigates the complex biochemical mechanisms underlying aging by analyzing primary human fibroblasts using a longitudinal multi-omics dataset. This dataset includes cytology, DNA methylation and epigenetic clocks, bioenergetics, mitochondrial DNA sequencing, RNA sequencing, and cytokine profiling. Key findings indicate that mitochondrial efficiency declines with age, while glycolysis becomes more...

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Literature Corpus work
d56efc20-618a-5ca5-ac04-882967cf0f84
DOI
10.1101/2025.05.17.654671
Open publication

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