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Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured Fibroblasts

2019-04-10

Abstract excerpt

<h4>Summary</h4> Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in vitro . Here we culture primary human fibroblasts across the cellular lifespan (∼6 months) and use four different DNAm clocks to show that age-relat...

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Literature Corpus work
278543a3-bf2a-56e7-bcad-a3521af4db09
DOI
10.1101/605295
Open publication

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Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured FibroblastsDOI 10.1101/605295
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