Article

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation

2024-07-07

Abstract excerpt

<h4>SUMMARY</h4> Health is strongly affected by aging and lifespan-modulating interventions, but the molecular mechanisms of mortality regulation remain unclear. Here, we conducted an RNA-seq analysis of mice subjected to 20 compound treatments in the Interventions Testing Program (ITP). By integrating it with the data from over 4,000 rodent tissues representing aging and responses to genetic, pharmacological, an...

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Literature Corpus work: 471819ed-9e7f-55aa-a452-3cdcb66da966
DOI: 10.1101/2024.07.04.601982

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