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Aging in Fast-Forward: An Inducible SIRT6 Deficiency model as a Lens on Brain Aging and Neurodegeneration

2026-02-17

Abstract excerpt

Aging and neurodegeneration occur gradually, making in vitro modeling challenging and costly. We generated a time-resolved, reversible neuron-like aging model by gradually depleting SIRT6. Within three weeks, their transcriptomes recapitulated brain-aging signatures and hallmarks. RNA-seq revealed clusters of nonlinear changes and predicted oscillatory DNA-damage and apoptotic programs, allowing stress response an...

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Literature Corpus work
363dc3c0-98ee-5852-af95-f1dbaad2f7b3
DOI
10.64898/2026.02.15.705977
Open publication

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Aging in Fast-Forward: An Inducible SIRT6 Deficiency model as a Lens on Brain Aging and NeurodegenerationDOI 10.64898/2026.02.15.705977
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