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Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma

2025-07-11

Abstract excerpt

<h4>Background and Aims</h4> Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy. Yet, their efficacy in hepatocellular carcinoma (HCC) remains limited, partly due to tumor-intrinsic mechanisms of immune evasion. This study focused on the identification of potential epigenetic drivers of immune resistance in HCC evaluating the therapeutic potential of targeting the histone methyltransferase G9a...

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Literature Corpus work
237a03db-1fcd-580f-b55e-cad90af5a6bd
DOI
10.1101/2025.07.08.663670
Open publication

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Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinomaDOI 10.1101/2025.07.08.663670
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