Article

Cell-free, methylated DNA in blood samples reveals tissue-specific, cellular damage from radiation treatment

2022-04-13

Abstract excerpt

Radiation therapy is an effective cancer treatment although damage to healthy tissues is common. Here we characterize the methylomes of healthy human and mouse tissues to establish sequencing-based, cell-type specific reference DNA methylation atlases. Identified cell-type specific DNA blocks were mostly hypomethylated and located within genes intrinsic to cellular identity. Cell-free DNA fragments released from d...

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Literature Corpus work: ed3e5f58-fa57-536b-ad0d-34bfe7f64070
DOI: 10.1101/2022.04.12.487966

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