Article

Immune checkpoint inhibitor response in sarcomas associates with immune infiltrates and increased expression of transposable elements and viral response pathways

2024-01-03

Abstract excerpt

<h4>ABSTRACT</h4> Response to immune checkpoint inhibition (ICI) in sarcoma is overall low and heterogeneous. Understanding determinants of ICI outcomes may improve efficacy and patient selection. One potential mechanism is epigenetic de-repression of transposable elements (TEs), which stimulates antitumor immunity. Here, we used transcriptomic data to assign immune-hot versus immune-cold status to 67 pre-treatmen...

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Literature Corpus work: 062879d0-772b-5815-b511-ae8399f9ea4c
DOI: 10.1101/2024.01.02.24300710

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