Article

Quantifying annotation-stratified pleiotropy and co-polygenicity between complex traits

2026-06-09

Abstract excerpt

Understanding shared genetic architecture is essential to interpreting disease comorbidities and trait correlations. We introduce SBayesAPP, a Bayesian model that integrates GWAS summary statistics with functional annotations to jointly estimate annotation-stratified SNP effect-size correlation and pleiotropic variant proportion (co-polygenicity) between traits, dissecting genetic correlation and coheritability en...

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Literature Corpus work: 4c271b90-a178-5fc9-ba5f-d6996673a803
DOI: 10.64898/2026.06.04.730246

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