Master regulators governing protein abundance across ten human cancer types

Abstract excerpt

<h4>ABSTRACT</h4> Protein abundance correlates only moderately with mRNA levels, and are modulated post-transcriptionally by a network of regulators including ribosomes, RNA-binding proteins (RBPs), and the proteasome. Here, we identified Ma ster P rotein abundance R egulators (MaPRs) across ten cancer types by devising a new computational pipeline that jointly analyzed transcriptomes and proteomes from 1,305...

Topics

Open a Topic to create a Post that cites this publication.

• Advanced Proteomics Techniques and Applications
• Bioinformatics and Genomic Networks
• Cancer-related Molecular Pathways
• Cell Line, Tumor
• Ferroptosis and cancer prognosis
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Mass Spectrometry

Identifiers and source

Literature Corpus work

72ca2caa-ba94-536b-8744-792ac16f5d9b

DOI

10.1101/2024.11.11.619147