SLE non-coding Genetic Risk Variant Determines the Epigenetic Dysfunction of an Immune Cell Specific Enhancer that Controls Disease-critical microRNA Expression

Abstract excerpt

The human genome contains millions of putative regulatory elements, which regulate gene expression. We are just beginning to understand the functional consequences of genetic variation within these regulatory elements. Since the bulk of common genetic variation impacting polygenic disease phenotypes localizes to these non-coding regions of the genome, understanding the consequences will improve our understanding o...

Topics

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• CRISPR-Cas Systems
• Healthy Volunteers
• Interferon Type I
• Leukocytes, Mononuclear
• NF-kappa B
• Primary Cell Culture
• Regulatory Sequences, Nucleic Acid
• RNA-Seq

Identifiers and source

Literature Corpus work

bfcf0bce-c236-567f-b940-f620a4945cc5

DOI

10.1101/2020.05.13.092932