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Article

A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus.

PLoS genetics - 1 Jun 2011

Luo Xiaobing, Yang Wanling, Ye Dong-Qing, Cui Huijuan, Zhang Yan, Hirankarn Nattiya, Qian Xiaoxia, Tang Yuanjia, Lau Yu Lung, de Vries Niek, Tak Paul Peter, Tsao Betty P, Shen Nan

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a strong genetic predisposition, characterized by an upregulated type I interferon pathway. MicroRNAs are important regulators of immune homeostasis, and aberrant microRNA expression has been demonstrated in patients with autoimmune diseases. We recently identified miR-146a as a negative regulator of the interferon pathway and linked the...

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PMID: 21738483
DOI: 10.1371/journal.pgen.1002128
PMCID: PMC3128113

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ETS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus.PMID 21738483Read ↗

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