Article

Mutational Signatures as Sensors of Environmental Exposures: Role of Smoking in COVID-19 Vulnerabilities

2021-09-28

Abstract excerpt

<h4>Background</h4> Environmental exposures such as smoking are widely recognized risk factors in the emergence of lung diseases including lung cancer and acute respiratory distress syndrome (ARDS). However, the strength of environmental exposures is difficult to measure, making it challenging to understand their impacts. On the other hand, some COVID-19 patients develop ARDS in an unfavorable disease progression...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bfca0ddc-b1aa-5ddb-9ed9-5d9bba5d7469
DOI: 10.1101/2021.09.27.461855

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutational Signatures as Sensors of Environmental Exposures: Role of Smoking in COVID-19 VulnerabilitiesDOI 10.1101/2021.09.27.461855Read

Tobacco smoke alters the trajectory of lung adenocarcinoma evolution via effects on somatic selection and epistasisSemantic proximity Read

Mutational Signatures as Sensors of Environmental Exposures: Analysis of Smoking-Induced Lung Tissue Remodeling.Semantic proximity Read

From tobacco smoking to mutational signature: the role of epigenetic changes in human cancersSemantic proximity Read

Common pathogenic mechanisms and pathways in the development of COPD and lung cancer.Semantic proximity Read

Smoking-Mediated Upregulation of the Androgen Pathway Leads to Increased SARS-CoV-2 SusceptibilitySemantic proximity Read

Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation.Semantic proximity Read

The mutagenic forces shaping the genomic landscape of lung cancer in never smokersSemantic proximity Read

From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes.Semantic proximity Read

Mutational signatures associated with tobacco smoking in human cancerSemantic proximity Read

Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers.Semantic proximity Read

The mutagenic forces shaping the genomes of lung cancer in never smokers.Semantic proximity Read

APOBEC shapes tumor evolution and age at onset of lung cancer in smokersSemantic proximity Read