Article
The mutagenic forces shaping the genomes of lung cancer in never smokers.
Nature - 1 Aug 2025
Díaz-Gay Marcos, Zhang Tongwu, Hoang Phuc H, Leduc Charles, Baine Marina K, Travis William D, Sholl Lynette M, Joubert Philippe, Khandekar Azhar, Zhao Wei, Steele Christopher D, Otlu Burçak, Nandi Shuvro P, Vangara Raviteja, Bergstrom Erik N, Kazachkova Mariya, Pich Oriol, Swanton Charles, Hsiung Chao Agnes, Chang I-Shou, Wong Maria Pik, Leung Kin Chung, Sang Jian, McElderry John P, Hartman Caleb, Colón-Matos Frank J, Miraftab Mona, Saha Monjoy, Lee Olivia W, Jones Kristine M, Gallego-García Pilar, Yang Yang, Zhong Xiaoming, Edell Eric S, Santamaría Jacobo Martínez, Schabath Matthew B, Yendamuri Sai S, Manczuk Marta, Lissowska Jolanta, Świątkowska Beata, Mukeria Anush, Shangina Oxana, Zaridze David, Holcatova Ivana, Mates Dana, Milosavljevic Sasa, Kontic Milica, Bossé Yohan, Rothberg Bonnie E Gould, Christiani David C, Gaborieau Valerie, Brennan Paul, Liu Geoffrey, Hofman Paul, Yang Lixing, Nowak Martin A, Shi Jianxin, Rothman Nathaniel, Wedge David C, Homer Robert, Yang Soo-Ryum, Pesatori Angela C, Consonni Dario, Lan Qing, Zhu Bin, Chanock Stephen J, Choi Jiyeon, Alexandrov Ludmil B, Landi Maria Teresa
Abstract excerpt
Lung cancer in never smokers (LCINS) accounts for around 25% of all lung cancers1,2 and has been associated with exposure to second-hand tobacco smoke and air pollution in observational studies3-5. Here we use data from the Sherlock-Lung study to evaluate mutagenic exposures in LCINS by examining the cancer genomes of 871 treatment-naive individuals with lung cancer who had never smoked, from 28 geographical...
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