Article
Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers.
American journal of epidemiology - 1 Jun 2021
Landi Maria Teresa, Synnott Naoise C, Rosenbaum Jennifer, Zhang Tongwu, Zhu Bin, Shi Jianxin, Zhao Wei, Kebede Michael, Sang Jian, Choi Jiyeon, Mendoza Laura, Pacheco Marwil, Hicks Belynda, Caporaso Neil E, Abubakar Mustapha, Gordenin Dmitry A, Wedge David C, Alexandrov Ludmil B, Rothman Nathaniel, Lan Qing, Garcia-Closas Montserrat, Chanock Stephen J
Abstract excerpt
Epidemiologic studies often rely on questionnaire data, exposure measurement tools, and/or biomarkers to identify risk factors and the underlying carcinogenic processes. An emerging and promising complementary approach to investigate cancer etiology is the study of somatic "mutational signatures" that endogenous and exogenous processes imprint on the cellular genome. These signatures can be identified from a...
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