Article

Innovations in Drug Discovery for Sickle Cell Disease Targeting Oxidative Stress and NRF2 Activation – A Short Review

2025-03-10

Abstract excerpt

Sickle cell disease (SCD) is a monogenic blood disorder characterized by abnormal hemoglobin S production, which polymerizes under hypoxia conditions to produce chronic hemolysis, widespread organ damage, and vasculopathy. As a result of vaso-occlusion and ischemia-reperfusion injury, individuals with SCD have recurrent pain episodes, infection, pulmonary disease and fall victim to early death. Oxidative stress du...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a78ac119-7e11-5548-8405-940b7ae66b2b
DOI: 10.20944/preprints202503.0572.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Innovations in Drug Discovery for Sickle Cell Disease Targeting Oxidative Stress and NRF2 Activation – A Short ReviewDOI 10.20944/preprints202503.0572.v1Read

Keap1-Nrf2 Heterodimer: A Therapeutic Target to Ameliorate Sickle Cell DiseaseSemantic proximity Read

Sickle Cell Disease: Role of Oxidative Stress and Antioxidant TherapySemantic proximity Read

Ferroptosis as an emerging target in sickle cell diseaseSemantic proximity Read

Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches.Semantic proximity Read

Decoding the role of SOD2 in sickle cell diseaseSemantic proximity Read

Nrf2 sensitizes ferroptosis through L-2-hydroxyglutarate-mediated chromatin modifications in sickle cell diseaseSemantic proximity Read

Sickle Cell DiseaseSemantic proximity Read

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model.Semantic proximity Read

Sickle Cell Anemia and Inflammation: A Review of Stones and Landmarks Paving the Road in the Last 25 YearsSemantic proximity Read

Biomarkers and recent advances in the management and therapy of sickle cell diseaseSemantic proximity Read

Oxidative stress in sickle cell diseaseSemantic proximity Read

Crosstalk Between Sickle Cell Disease and FerroptosisSemantic proximity Read