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Article

Ferroptosis is a Physiologic Vulnerability of Iron-Recycling Macrophages

2026-06-26

Abstract excerpt

<h4>Summary</h4> Iron deficiency anemia affects one-third of the global human population. Paradoxically, the daily iron required to fuel the production red blood cell (RBC) and prevent anemia is provided through its recycling from senescent RBC. This is achieved by splenic red pulp macrophages (RPM) that extract iron from the heme groups of hemoglobin (Hb). How these professional erythrophagocytic macrophages pre...

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Literature Corpus work
0956284b-cdc6-5ded-814a-4cba0018d66e
DOI
10.64898/2026.06.22.732688
Open publication

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Ferroptosis is a Physiologic Vulnerability of Iron-Recycling MacrophagesDOI 10.64898/2026.06.22.732688
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