Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes

10 Jan 2019

Abstract excerpt

Unmasking an agent of inflammatory anemia Infectious and autoimmune diseases are associated with anemia and thrombocytopenia. A severe form of inflammatory cytopenia called macrophage activation syndrome (MAS) may occur during rheumatological disorders and viral infections. Akilesh et al. show that monocyte recognition of self- or pathogen-derived nucleic acids via Toll-like receptors 7 and 9 (TLR7 and TLR9)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune and Inflammatory Disorders Research
Share to Immune Cell Function and Interaction
Share to Inflammasome and immune disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30630901
DOI: 10.1126/science.aao5213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytesPMID 30630901Read ↗

Myeloid IRF5 is required for TLR7-driven inflammatory hemophagocyte differentiation and Macrophage Activation SyndromeSemantic proximity Read ↗

Erythrophagocytes in hemolytic anemia, wound healing, and cancerSemantic proximity Read ↗

Monocytes and Macrophages in COVID-19Semantic proximity Read ↗

Occurrences and Functions of Ly6Chi and Ly6Clo Macrophages in Health and DiseaseSemantic proximity Read ↗

Heme-stress activated NRF2 signaling skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophagesSemantic proximity Read ↗

From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and ErythrophagocytosisSemantic proximity Read ↗

Macrophage activation syndrome: advances towards understanding pathogenesisSemantic proximity Read ↗

Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes.Semantic proximity Read ↗

Heterogeneity of macrophage activation syndrome and treatment progressionSemantic proximity Read ↗

Thrombocytopenia Independently Leads to Monocyte Immune DysfunctionSemantic proximity Read ↗

Macrophage activation syndrome: early diagnosis is keySemantic proximity Read ↗

Hemophagocytic Lymphohistiocytosis Secondary to Macrophage Activation Syndrome in Adult-Onset Still’s Disease: A Diagnostic and Therapeutic ChallengeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.