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Role of Macrophages in Sickle Cell Disease Erythrophagocytosis and Erythropoiesis

28 Mar 2023

Abstract excerpt

Sickle cell disease (SCD) is an inherited blood disorder caused by a β-globin gene point mutation that results in the production of sickle hemoglobin that polymerizes upon deoxygenation, causing the sickling of red blood cells (RBCs). RBC deformation initiates a sequence of events leading to multiple complications, such as hemolytic anemia, vaso-occlusion, chronic inflammation, and tissue damage. Macrophages...

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PMID: 37047304
DOI: 10.3390/ijms24076333

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