Article

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA-protein crosslinks <i>in vivo</i>

2023-03-01

Abstract excerpt

DNA-protein crosslinks (DPCs) are frequent and damaging DNA lesions that affect all DNA transactions, which in turn can lead to the formation of DSBs, genomic instability and cell death. At the organismal level, impaired DPC repair (DPCR) is associated with cancer, aging, and neurodegeneration. Despite the severe consequences of DPCs, little is known about the processes underlying repair pathways at the organism l...

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Literature Corpus work: bf8cf2a9-6854-5918-9abd-1a1496b8973f
DOI: 10.1101/2023.03.01.530659

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