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Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease

15 Jun 2022

Abstract excerpt

DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are covalently crosslinked to the DNA by the action of variety of agents like reactive oxygen species, aldehydes and metabolites, radiation, and chemotherapeutic drugs. Unrepaired DPCs are blockades to all DNA metabolic processes. Specifically, during DNA replication, replication forks stall at DPCs and are vulnerable to fork...

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PMID: 35782873
DOI: 10.3389/fmolb.2022.916697

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