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Article

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

The Journal of biological chemistry - 28 Oct 2005

Interthal Heidrun, Chen Hong Jing, Champoux James J

Abstract excerpt

Human tyrosyl-DNA phosphodiesterase (Tdp1) hydrolyzes the phosphodiester bond between a DNA 3' end and a tyrosyl moiety. In eukaryotic cells, this type of linkage is found in stalled topoisomerase I-DNA covalent complexes, and Tdp1 has been implicated in the repair of such complexes in vivo. We confirm here that the Tdp1 catalytic cycle involves a covalent reaction intermediate in which a histidine residue is...

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Identifiers

PMID: 16141202
DOI: 10.1074/jbc.M508898200
PMCID: PMC1351008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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