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Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes

6 Apr 2023

Abstract excerpt

Topoisomerase IIIα (TOP3A) belongs to the conserved Type IA family of DNA topoisomerases. Here we report that human TOP3A is associated with DNA replication forks and that a "self-trapping" TOP3A mutant (TOP3A-R364W) generates cellular TOP3A DNA cleavage complexes (TOP3Accs). We show that trapped TOP3Accs that interfere with replication, induce DNA damage and genome instability. To elucidate how TOP3Accs are...

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PMID: 37024461
DOI: 10.1038/s41467-023-37498-6

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