Article

Directional Variant Tension (T <sub>v</sub> ): A Causal Framework for Quantifying Substitution Asymmetry

2026-03-12

Abstract excerpt

Amino acid substitutions are often directionally asymmetric due to underlying biophysical constraints and diverse evolutionary pressures. We introduce T v (variant tension), a kernel regression-based metric that quantifies this directional asymmetry directly from aligned multiple sequence alignments (MSAs). T v leverages empirical amino acid frequencies and a non-parametric Gaussian kernel to capture nonlinear s...

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Literature Corpus work: bf840b5f-ee43-53ce-b3e1-f62008182d94
DOI: 10.64898/2026.03.10.710752

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