Amino acid exchangeability and surface accessibility underpin the effects of single substitutions.

Abstract excerpt

Deep mutational scans have measured the effects of many mutations on a large variety of proteins. We use a collection of these scans to perform a meta-analysis of the effects of single amino acid substitutions, modeling the relative deleteriousness of each substitution with respect to the surface accessibility of the wildtype residue and the identities of the amino acids being exchanged. This simple model...

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