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Article

Dynamics-aware evolutionary profiling uncouples structural rigidity from functional motion to enable enhanced variant interpretation.

Functional & integrative genomics - 22 Aug 2026

Karagöl Taner, Karagöl Alper

Abstract excerpt

Evolutionary conservation is a powerful part of mutational intolerance prediction, yet traditional pathogenicity metrics frequently conflate two distinct biophysical constraints: structural stability (rigidity) and functional mechanics (dynamics). We introduce Dynamics-Aware Evolutionary Profiling to resolve this ambiguity, integrating Molecular Dynamics with evolutionary conservation and coupling analysis across...

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PMID: 42629527
DOI: 10.1007/s10142-026-02013-9

Genes

NARS1
PGK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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