Article

Allostery is a widespread cause of loss-of-function variant pathogenicity

2025-06-25

Abstract excerpt

Allosteric communication between non-contacting sites in proteins plays a fundamental role in biological regulation and drug action. While allosteric gain-of-function variants are known drivers of oncogene activation, the broader importance of allostery in genetic disease and protein evolution is less clear. Here, we integrate large-scale experimental measurements and neural network models to provide evidence that...

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Literature Corpus work: d28b1151-65d5-5d31-b68a-90042f8c575b
DOI: 10.1101/2025.06.20.660737

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