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Article

Accounting for epistatic interactions improves the functional analysis of protein structures.

Bioinformatics (Oxford, England) - 1 Nov 2013

Wilkins Angela D, Venner Eric, Marciano David C, Erdin Serkan, Atri Benu, Lua Rhonald C, Lichtarge Olivier

Abstract excerpt

MOTIVATION: The constraints under which sequence, structure and function coevolve are not fully understood. Bringing this mutual relationship to light can reveal the molecular basis of binding, catalysis and allostery, thereby identifying function and rationally guiding protein redesign. Underlying these relationships are the epistatic interactions that occur when the consequences of a mutation to a protein are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24021383
DOI: 10.1093/bioinformatics/btt489
PMCID: PMC3799481

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