Insights from modeling protein evolution with context-dependent mutation and asymmetric amino acid selection.

Abstract excerpt

We develop an approximate maximum likelihood method to estimate flanking nucleotide context-dependent mutation rates and amino acid exchange-dependent selection in orthologous protein-coding sequences and use it to analyze genome-wide coding sequence alignments from mammals and yeast. Allowing context-dependent mutation provides a better fit to coding sequence data than simpler (context-independent or CpG...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amino Acids
• Share to Computer Simulation
• Share to Evolution, Molecular