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Article

Predicting hotspots for disease-causing single nucleotide variants using sequences-based coevolution, network analysis, and machine learning.

PloS one - 1 Jan 2024

Zheng Wenjun

Abstract excerpt

To enable personalized medicine, it is important yet highly challenging to accurately predict disease-causing mutations in target proteins at high throughput. Previous computational methods have been developed using evolutionary information in combination with various biochemical and structural features of protein residues to discriminate neutral vs. deleterious mutations. However, the power of these methods is...

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PMID: 38743747
DOI: 10.1371/journal.pone.0302504
PMCID: PMC11093321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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