Co-evolution of alpha-helical transmembrane protein residues: large-scale variant profiling and complete mutational landscape of 2277 known PDB entries representing 504 unique human protein sequences.

Abstract excerpt

Membrane proteins play fundamental roles in cellular function, yet the evolutionary dynamics of their amino acid composition remain poorly understood. Our current study investigates the substitutional landscape and evolutionary patterns of hydrophilic and hydrophobic residues in membrane α-helical proteins, addressing a significant gap in our knowledge of protein evolution. We analyzed 2277 high-resolution...

Topics

• Humans
• Evolution, Molecular
• Membrane Proteins
• Databases, Protein
• Amino Acid Substitution
• Mutation
• Protein Conformation, alpha-Helical
• Amino Acid Sequence
• Hydrophobic and Hydrophilic Interactions