Article

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

2022-03-21

Abstract excerpt

<title>Abstract</title> <p>Autosomal dominant mutations in α-synuclein, TDP-43 and tau promote protein aggregation and neurodegeneration. Rates of aggregation are highly dependent on protein concentration, which can be regulated via lysosomal proteolysis. Lysosomal cathepsins recognize specific linear amino acid sequences; thus, mutations in α-synuclein, TDP-43 and tau have the potential to impact protein half-li...

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Literature Corpus work: bf7c2b59-4f32-5aa7-837a-424be9487002
DOI: 10.21203/rs.3.rs-1451319/v1

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