Article
Tau Accumulation in Degradative Organelles is Associated to Lysosomal Stress
2023-05-25
Abstract excerpt
Neurodegenerative disorders are characterized by the brain deposition of insoluble amyloidogenic proteins, such as α-synuclein or Tau, and the concomitant deterioration of cell functions such as the autophagy-lysosomal pathway (ALP). The ALP is involved in the degradation of intracellular macromolecules including protein aggregates. ALP dysfunction due to inherited defects in lysosomal or non-lysosomal proteins ca...
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Identifiers and source
- Literature Corpus work
- 81ad92e1-a318-55d2-a50b-7ec9f7151784
- DOI
- 10.21203/rs.3.rs-2972040/v1