Article

Linking Thrombin to α-Synuclein truncation reveals a molecular bridge between neuroinflammation and Parkinson disease

2025-11-18

Abstract excerpt

<title>Abstract</title> <p>Proteolytic processing of α-Synuclein (Syn) contributes to the molecular diversity and toxicity of its aggregates in Parkinson disease (PD), yet the proteases responsible for generating disease-relevant truncations remain incompletely defined. Here, we identify thrombin (Thb) — a serine protease best known for its role in haemostasis — as a highly selective Syn-processing enzyme with re...

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Literature Corpus work: ddd9842e-c5ac-5f72-9281-912eb0009e65
DOI: 10.21203/rs.3.rs-8050047/v1

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