Article

The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

2024-03-19

Abstract excerpt

<title>Abstract</title> <p>Background Variants in the <italic>CTSB</italic> gene encoding the lysosomal hydrolase cathepsin B (catB) are associated with increased risk of Parkinson’s disease (PD). However, neither the specific <italic>CTSB</italic> variants driving these associations nor the functional pathways that link catB to PD pathogenesis have been characterized. CatB activity contributes to lysosomal prot...

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Literature Corpus work: c44264b2-ab18-5570-8933-796222768d00
DOI: 10.21203/rs.3.rs-3979098/v1

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