Article

From Evasion to Collapse: The Kinetic Cascade of TDP-43 and the Failure of Proteostasis

2025-12-16

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating and currently untreatable neurodegenerative diseases, whose genetic and molecular etiologies remain largely unclear. The histopathological hallmark of both diseases is the cytoplasmic deposition of TDP-43 in neurons, which is attributed to both intrinsic (e.g., mutations, aberrant cleavage) and extrinsic factors (e.g., prolonged...

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Literature Corpus work: 31d857c0-c5c4-50bf-9f73-d21bc30e0524
DOI: 10.20944/preprints202512.1433.v1

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