Article
The ubiquitin protein catabolic disorders.
Neuropathology and applied neurobiology - 1 Jun 2001
Layfield R, Alban A, Mayer R J, Lowe J
Abstract excerpt
The ubiquitin-proteasome system of intracellular proteolysis is essential for cell viability. We propose the concept that neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as other conditions including some types of cancer, collectively represent a raft of 'ubiquitin protein...
Topics
- Alzheimer Disease
- Cysteine Endopeptidases
- Humans
- Inclusion Bodies
- Metabolic Diseases
- Multienzyme Complexes
- Mutation
- Neurons
- Proteasome Endopeptidase Complex
- Protein Processing, Post-Translational
- Ubiquitins