Article

Lysosomal Protease-Mediated APP Degradation is pH-Dependent, Mutation-Sensitive, and Facilitates Tau Proteolysis

2025-07-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> The accumulation and aggregation of amyloid beta (A\(\beta\))---a peptide fragment derived from the proteolytic processing of amyloid precursor protein (APP)---is a central pathological feature of Alzheimer’s disease (AD) and a current target for disease-modifying therapies. Mutations in APP can also drive early-onset AD. While the roles of \(\alpha\)-, $\beta$-...

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Literature Corpus work: a0d9f7b3-c65b-510e-9710-9ab4fe452ec8
DOI: 10.21203/rs.3.rs-6978813/v1

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