Article
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Molecular neurodegeneration - 2 May 2023
Sampognaro Paul J, Arya Shruti, Knudsen Giselle M, Gunderson Emma L, Sandoval-Perez Angelica, Hodul Molly, Bowles Kathryn, Craik Charles S, Jacobson Matthew P, Kao Aimee W
Abstract excerpt
BACKGROUND: Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to predispose to neurodegeneration by enhancing protein aggregation. While a subset of α-synuclein, TDP-43 and tau mutations has been shown to increase the structural propensity of these proteins toward self-association, rates of aggregation are also highly dependent on protein steady state concentrations, which are in large part...
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