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Article

Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.

Experimental & molecular medicine - 13 Mar 2015

Ciechanover Aaron, Kwon Yong Tae

Abstract excerpt

Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the UPS, in which Ub-conjugated substrates are deubiquitinated, unfolded and cleaved into small peptides when passing through the narrow chamber of the proteasome. The substrates...

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Identifiers

PMID: 25766616
DOI: 10.1038/emm.2014.117
PMCID: PMC4351408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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