Article

Constitutive UPR <sup>ER</sup> activation sustains tumor cell differentiation

2019-03-31

Abstract excerpt

Endoplasmic Reticulum (ER) proteostasis control and the Unfolded Protein Response (UPR ER ) have been shown to contribute to tumor development and aggressiveness. As such, the UPR ER sensor IRE1α (referred to as IRE1 hereafter) is a major regulator of glioblastoma (GBM) development and is an appealing therapeutic target. To document IRE1 suitability as an antineoplastic pharmacological target, we investigated ho...

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Literature Corpus work: bf5c8ec1-3d72-5096-a32f-9609024e096b
DOI: 10.1101/594630

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