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Article

The multiple roles of the unfolded protein response regulator IRE1α in cancer

30 Apr 2019

Abstract excerpt

Cancer is associated with a number of conditions such as hypoxia, nutrient deprivation, cellular redox, and pH changes that result in accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) and trigger a stress response known as the unfolded protein response (UPR). The UPR is a conserved cellular survival mechanism mediated by the ER transmembrane proteins activating transcription factor...

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PMID: 31041814
DOI: 10.1002/mc.23031

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