Article

Expression of key unfolded protein response genes predicts patient survival and an immunosuppressive microenvironment in glioblastoma

2023-10-11

Abstract excerpt

<title>Abstract</title> <p>Background Dysregulation of cellular processes related to protein folding and trafficking leads to the accumulation of misfolded proteins in the endoplasmic reticulum (ER), triggering ER stress. Cells cope with ER stress by activating the unfolded protein response (UPR), a signaling pathway that has been implicated in a variety of diseases, including cancer. However, the role of the UP...

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Literature Corpus work: 94183df7-9999-5a73-b4c5-72e0991cbe9d
DOI: 10.21203/rs.3.rs-3407414/v1

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