Dual IRE1 RNase functions dictate glioblastoma development.

doi:10.15252/emmm.201707929

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Article

Dual IRE1 RNase functions dictate glioblastoma development.

EMBO molecular medicine - 1 Mar 2018

Lhomond Stéphanie, Avril Tony, Dejeans Nicolas, Voutetakis Konstantinos, Doultsinos Dimitrios, McMahon Mari, Pineau Raphaël, Obacz Joanna, Papadodima Olga, Jouan Florence, Bourien Heloise, Logotheti Marianthi, Jégou Gwénaële, Pallares-Lupon Néstor, Schmit Kathleen, Le Reste Pierre-Jean, Etcheverry Amandine, Mosser Jean, Barroso Kim, Vauléon Elodie, Maurel Marion, Samali Afshin, Patterson John B, Pluquet Olivier, Hetz Claudio, Quillien Véronique, Chatziioannou Aristotelis, Chevet Eric

Abstract excerpt

Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical role in cancer development. This concept is valid in glioblastoma multiform (GBM), the most lethal primary brain cancer with no effective treatment. We previously demonstrated that the ER stress...

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Identifiers

PMID: 29311133
DOI: 10.15252/emmm.201707929
PMCID: PMC5840541

Genes

XBP1

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