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Article

ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation

11 Feb 2022

Abstract excerpt

The growth of glioblastoma (GBM), one of the deadliest adult cancers, is fuelled by a subpopulation of stem/progenitor cells, which are thought to be the source of resistance and relapse after treatment. Re-engagement of a latent capacity of these cells to re-enter a trajectory resulting in cell differentiation is a potential new therapeutic approach for this devastating disease. ASCL1, a proneural transcription...

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PMID: 35149717
DOI: 10.1038/s41598-022-06248-x

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