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The Unfolded Protein Response: A Novel Therapeutic Target in Acute Leukemias

1 Feb 2020

Abstract excerpt

The unfolded protein response (UPR) is an evolutionarily conserved adaptive response triggered by the stress of the endoplasmic reticulum (ER) due, among other causes, to altered cell protein homeostasis (proteostasis). UPR is mediated by three main sensors, protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor 6α (ATF6α), and inositol-requiring enzyme-1α (IRE1α). Given that...

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PMID: 32024211
DOI: 10.3390/cancers12020333

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