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The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance

10 Oct 2018

Abstract excerpt

Tumour cells endure both oncogenic and environmental stresses during cancer progression. Transformed cells must meet increased demands for protein and lipid production needed for rapid proliferation and must adapt to exist in an oxygen- and nutrient-deprived environment. To overcome such challenges, cancer cells exploit intrinsic adaptive mechanisms such as the unfolded protein response (UPR). The UPR is a...

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PMID: 30302777
DOI: 10.1111/boc.201800050

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