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The unfolded protein response as regulator of cancer stemness and differentiation: Mechanisms and implications for cancer therapy

16 Aug 2021

Abstract excerpt

The unfolded protein response (UPR) is an adaptive mechanism that regulates protein and cellular homeostasis. Three endoplasmic reticulum (ER) membrane localized stress sensors, IRE1, PERK and ATF6, coordinate the UPR in order to maintain ER proteostasis and cell survival, or induce cell death when homeostasis cannot be restored. However, recent studies have identified alternative functions for the UPR in...

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PMID: 34411568
DOI: 10.1016/j.bcp.2021.114737

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