Article

Alternative splicing of transposable elements in human breast cancer

2024-09-29

Abstract excerpt

Transposable elements (TEs) drive genome evolution and can affect gene expression through diverse mechanisms. In breast cancer, disrupted regulation of TE sequences may facilitate tumor-specific transcriptomic alterations. We examine 142,514 full-length isoforms derived from long-read RNA sequencing (LR-seq) of 30 breast samples to investigate the effects of TEs on the breast cancer transcriptome. Approximately ha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b3e5063-0116-5974-87ee-28f807d6a255
DOI: 10.1101/2024.09.26.615242

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alternative splicing of transposable elements in human breast cancerDOI 10.1101/2024.09.26.615242Read

Comprehensive analysis of retrotransposons (LTR and non-LTR) in breast cancerSemantic proximity Read

Patterns of Transposable Element Expression and Insertion in CancerSemantic proximity Read

Transcriptomic splicing analysis reveals a gene-independent form of TE reactivation in tumors representing unrecognized source of oncogenes and neoantigensSemantic proximity Read

Long-read isoform sequencing reveals survival-associated splicing in breast cancerSemantic proximity Read

Atlas of transcriptionally active transposable elements in human adult tissuesSemantic proximity Read

FREDDIE: A comprehensive tool for detecting exonization of retrotransposable elements in short and long RNA sequencing dataSemantic proximity Read

TEITbase: a database for transposable element (TE)-initiated transcripts in human cancersSemantic proximity Read

Charting the regulatory landscape of TP53 on transposable elements in cancer.Semantic proximity Read

RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human CancerSemantic proximity Read

RNA splicing junction landscape reveals abundant tumor-specific transcripts in human cancer.Semantic proximity Read

Defining the regulatory logic of breast cancer using single-cell epigenetic and transcriptome profilingSemantic proximity Read

TEscape: Defining the human transposable element transcriptome using multiplatform long-read sequencingSemantic proximity Read