Article

Beyond HER2 expression in breast cancer: Investigating alternative splicing profiles as a mechanism of resistance to anti-HER2 therapies

2024-11-26

Abstract excerpt

Breast cancer is a heterogeneous disease that can be molecularly classified based on the expression of hormone receptors and the overexpression of the HER2 receptor (ERBB2). Targeted therapies for HER2-positive breast cancer, including trastuzumab, antibody drug conjugates (ADCs) and tyrosine kinase inhibitors, have significantly improved patient outcomes. However, both primary and acquired resistance to these tre...

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Literature Corpus work: bcf4f26a-c12a-5026-bcfd-9e27f37ec73e
DOI: 10.1101/2024.11.25.24317569

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